Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.

doi:10.1158/1055-9965.EPI-14-0680

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Article

Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2015

Milne Elizabeth, Greenop Kathryn R, Scott Rodney J, Haber Michelle, Norris Murray D, Attia John, Jamieson Sarra E, Miller Margaret, Bower Carol, Bailey Helen D, Dawson Somer, McCowage Geoffrey B, de Klerk Nicholas H, van Bockxmeer Frank M, Armstrong Bruce K

Abstract excerpt

BACKGROUND: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case-control study (2003-2007). METHODS: All Australian pediatric oncology centers...

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PMID: 25395472
DOI: 10.1158/1055-9965.EPI-14-0680

Genes

MTHFR
CBS
MTR
MTRR
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Source receipt: pubmed, retrieved 7 Sept 2026.

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