Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).

Cancer causes & control : CCC - 1 Aug 2012

Amigou Alicia, Rudant Jérémie, Orsi Laurent, Goujon-Bellec Stéphanie, Leverger Guy, Baruchel André, Bertrand Yves, Nelken Brigitte, Plat Geneviève, Michel Gérard, Haouy Stéphanie, Chastagner Pascal, Ducassou Stéphane, Rialland Xavier, Hémon Denis, Clavel Jacqueline

Abstract excerpt

PURPOSE: Fetal folate deficiency may increase the risk of subsequent childhood acute leukemia (AL), since folates are required for DNA methylation, synthesis, and repair, but the literature remains scarce. This study tested the hypothesis that maternal folic acid supplementation before or during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dietary Supplements
Share to Ferredoxin-NADP Reductase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Folic Acid Deficiency

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Pregnancy

Share to Pregnancy Complications

Source

Identifiers

PMID: 22706675
DOI: 10.1007/s10552-012-0004-0

Genes

MTHFR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22706675-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).PMID 22706675Read ↗

Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Gene-environment interactions and the risk of childhood acute lymphoblastic leukemia: exploring the role of maternal folate genes and folic Acid fortification.Semantic proximity Read ↗

Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study.Semantic proximity Read ↗

5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview.Semantic proximity Read ↗

Folate deficiency as predisposing factor for childhood leukaemia: a review of the literatureSemantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemiaSemantic proximity Read ↗

Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children.Semantic proximity Read ↗

Genetic variation in the folate metabolic pathway and risk of childhood leukemia.Semantic proximity Read ↗

Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis.Semantic proximity Read ↗

Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children.Semantic proximity Read ↗

A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.