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Article

Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).

Cancer causes & control : CCC - 1 Aug 2012

Amigou Alicia, Rudant Jérémie, Orsi Laurent, Goujon-Bellec Stéphanie, Leverger Guy, Baruchel André, Bertrand Yves, Nelken Brigitte, Plat Geneviève, Michel Gérard, Haouy Stéphanie, Chastagner Pascal, Ducassou Stéphane, Rialland Xavier, Hémon Denis, Clavel Jacqueline

Abstract excerpt

PURPOSE: Fetal folate deficiency may increase the risk of subsequent childhood acute leukemia (AL), since folates are required for DNA methylation, synthesis, and repair, but the literature remains scarce. This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394...

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Topics

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Share to Dietary Supplements
Share to Ferredoxin-NADP Reductase
Share to Folic Acid
Share to Folic Acid Deficiency
Share to Methylenetetrahydrofolate Reductase (NADPH2)
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma
Share to Pregnancy
Share to Pregnancy Complications

Source

Identifiers

PMID: 22706675
DOI: 10.1007/s10552-012-0004-0

Genes

MTHFR
MTRR

Variants

rs1801133
rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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