Folate Metabolism and Risk of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis from the Childhood Cancer and Leukemia International Consortium.

doi:10.1158/1055-9965.EPI-24-0189

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Folate Metabolism and Risk of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis from the Childhood Cancer and Leukemia International Consortium.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Sept 2024

Metayer Catherine, Spector Logan G, Scheurer Michael E, Jeon Soyoung, Scott Rodney J, Takagi Masatoshi, Clavel Jacqueline, Manabe Atsushi, Ma Xiaomei, Hailu Elleni M, Lupo Philip J, Urayama Kevin Y, Bonaventure Audrey, Kato Motohiro, Meirhaeghe Aline, Chiang Charleston W K, Morimoto Libby M, Wiemels Joseph L

Abstract excerpt

BACKGROUND: Prenatal folate supplementation has been consistently associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). Previous germline genetic studies examining the one carbon (folate) metabolism pathway were limited in sample size, scope, and population diversity and led to inconclusive results. METHODS: We evaluated whether ∼2,900 single-nucleotide polymorphisms (SNP) within 46...

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PMID: 38904462
DOI: 10.1158/1055-9965.EPI-24-0189
PMCID: PMC11369612

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