Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children.

Leukemia & lymphoma - 1 Apr 2007

Petra Bohanec Grabar, Janez Jazbec, Vita Dolzan

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Genetic polymorphisms in the folate metabolic pathway may contribute to the susceptibility to childhood ALL because they affect the DNA synthesis, methylation and repair. We analysed common genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR), thymidylate synthase (TS), methionine synthase (MS) and methionine synthase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folic Acid
Share to Metabolic Networks and Pathways
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Polymorphism, Genetic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Protein Interaction Mapping

Source

Identifiers

PMID: 17454638
DOI: 10.1080/10428190601187711

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children.PMID 17454638Read ↗

Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia.Semantic proximity Read ↗

Involvement of MTHFR and TPMT genes in susceptibility to childhood acute lymphoblastic leukemia (ALL) in Mexicans.Semantic proximity Read ↗

Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.Semantic proximity Read ↗

Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Polymorphisms in folate-related genes: impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese.Semantic proximity Read ↗

Is there a folate-related gene-environment interaction in the etiology of childhood acute lymphoblastic leukemia?Semantic proximity Read ↗

Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Genetic variation in the folate metabolic pathway and risk of childhood leukemia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children.Semantic proximity Read ↗

Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.