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Article

Genetic variation in the folate metabolic pathway and risk of childhood leukemia.

Blood - 13 May 2010

Lightfoot Tracy J, Johnston W Thomas, Painter Dan, Simpson Jill, Roman Eve, Skibola Chris F, Smith Martyn T, Allan James M, Taylor G Malcolm

Abstract excerpt

Studies of childhood leukemia and the potential etiologic role of genetic variation in folate metabolism have produced conflicting findings and have often been based on small numbers. We investigated the association between polymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del6, and TS 28bp repeat) in 939 cases of childhood acute lymphoblastic...

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Topics

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Share to Genetic Variation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Glycine Hydroxymethyltransferase

Share to Leukemia, Myeloid, Acute

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

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Identifiers

PMID: 20101025
DOI: 10.1182/blood-2009-10-249722
PMCID: PMC2869556

Genes

MTHFR
MTR
SHMT1

Provenance

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