Article
Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia.
Cancer causes & control : CCC - 1 Sept 2011
Metayer Catherine, Scélo Ghislaine, Chokkalingam Anand P, Barcellos Lisa F, Aldrich Melinda C, Chang Jeffrey S, Guha Neela, Urayama Kevin Y, Hansen Helen M, Block Gladys, Kiley Vincent, Wiencke John K, Wiemels Joseph L, Buffler Patricia A
Abstract excerpt
OBJECTIVE: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. METHODS: Seventy-six single nucleotide polymorphisms...
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