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Article

Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children.

Indian journal of cancer - 1 Jan 2000

Sadananda Adiga M N, Chandy S, Ramachandra N, Appaji L, Aruna Kumari B S, Ramaswamy G, Savithri H S, Krishnamoorthy L

Abstract excerpt

INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. Genetic polymorphisms of this enzyme have been shown to impact several diseases, including cancer. Leukemias are malignancies arising from rapidly proliferating hematopoietic cells having great requirement of DNA synthesis. This case-control study...

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PMID: 20071789
DOI: 10.4103/0019-509X.58858

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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