Article
Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014
Pyzik Michal, Dumaine Anne, Dumaine Anne A, Charbonneau Benoît, Fodil-Cornu Nassima, Jonjic Stipan, Vidal Silvia M
Abstract excerpt
The outcome of mouse CMV (MCMV) infection varies among different inbred mouse strains depending on NK cell effector functions governed through recognition receptor triggering. NK cells from different mouse strains possess diverse repertoires of activating or inhibitory Ly49 receptors, which share some of their polymorphic MHC class I (MHC-I) ligands. By examining the NK cell response to MCMV infection in novel...
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