Article
Self MHC class I-licensed NK cells enhance adaptive CD8 T-cell viral immunity.
Blood - 12 May 2011
Stadnisky Michael D, Xie Xuefang, Coats Ebony R, Bullock Timothy N, Brown Michael G
Abstract excerpt
MHC class I (MHC I) is essential to NK- and T-cell effector and surveillance functions. However, it is unknown whether MHC I polymorphism influences adaptive immunity through NK cells. Previously, we found that MHC I D(k), a cognate ligand for the Ly49G2 inhibitory receptor, was essential to NK control of murine (M)CMV infection. Here we assessed the significance of NK inhibitory receptor recognition of MCMV on...
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