Article
Ly49h is necessary for genetic resistance to murine cytomegalovirus.
Immunogenetics - 1 Oct 2008
Cheng Tammy P, French Anthony R, Plougastel Beatrice F M, Pingel Jeanette T, Orihuela Michael M, Buller Mark L, Yokoyama Wayne M
Abstract excerpt
Natural killer (NK) cells play critical roles in antiviral immunity. While the importance of effector mechanisms such as interferons has been demonstrated through knockout mice, specific mechanisms of how viruses are recognized and controlled by NK cells are less well defined. Previous genetic studies have mapped the resistance genes for murine cytomegalovirus (MCMV), herpes simplex virus-1 (HSV-1), and...
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