Article
Specific dysregulation of IFNγ production by natural killer cells confers susceptibility to viral infection.
PLoS pathogens - 1 Dec 2014
Fodil Nassima, Langlais David, Moussa Peter, Boivin Gregory Allan, Di Pietrantonio Tania, Radovanovic Irena, Dumaine Anne, Blanchette Mathieu, Schurr Erwin, Gros Philippe, Vidal Silvia Marina
Abstract excerpt
Natural Killer (NK) cells contribute to the control of viral infection by directly killing target cells and mediating cytokine release. In C57BL/6 mice, the Ly49H activating NK cell receptor plays a key role in early resistance to mouse cytomegalovirus (MCMV) infection through specific recognition of the MCMV-encoded MHC class I-like molecule m157 expressed on infected cells. Here we show that transgenic...
Topics
- Animals
- Chromosomes, Mammalian
- Cytomegalovirus
- Cytomegalovirus Infections
- Gene Expression Regulation, Viral
- Genetic Loci
- Genetic Predisposition to Disease
- Interferon-gamma
- Mice
- Mice, Knockout
- NK Cell Lectin-Like Receptor Subfamily A
- RNA Stability