Article
Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2008
Fodil-Cornu Nassima, Lee Seung-Hwan, Belanger Simon, Makrigiannis Andrew P, Biron Christine A, Buller R Mark, Vidal Silvia M
Abstract excerpt
Cmv1 was the first mouse cytomegalovirus (MCMV) resistance locus identified in C57BL/6 mice. It encodes Ly49H, a NK cell-activating receptor that specifically recognizes the m157 viral protein at the surface of MCMV-infected cells. To dissect the effect of the Ly49h gene in host-pathogen interactions, we generated C57BL/6 mice lacking the Ly49h region. We found that 36 h after MCMV infection, the lack of Ly49h...
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