Article
Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003
Voigt Valentina, Forbes Catherine A, Tonkin Joanne N, Degli-Esposti Mariapia A, Smith Hamish R C, Yokoyama Wayne M, Scalzo Anthony A
Abstract excerpt
Effective natural killer (NK) cell recognition of murine cytomegalovirus (MCMV)-infected cells depends on binding of the Ly49H NK cell activation receptor to the m157 viral glycoprotein. Here we addressed the immunological consequences of variation in m157 sequence and function. We found that most strains of MCMV possess forms of m157 that evade Ly49H-dependent NK cell activation. Importantly, repeated passage of...
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