Article
Cmv1-independent antiviral role of NK cells revealed in murine cytomegalovirus-infected New Zealand White mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2004
Rodriguez Marisela, Sabastian Pearl, Clark Patricia, Brown Michael G
Abstract excerpt
Ly49H(+) NK cells play a critical role in innate antiviral immune responses to murine CMV (MCMV). Ly49H(b6) recognition of MCMV-encoded m157 on infected cells activates natural killing required for host resistance. We show that mAb 3D10 (anti-Ly49H) recognizes comparable subsets of NK cells from New Zealand White (NZW), New Zealand Black (NZB), and C57BL/6 spleens. However, virus levels in the spleens of...
Topics
- Acute Disease
- Animals
- Antigens, Ly
- Antigens, Surface
- Cell Line
- Cytotoxicity, Immunologic
- Genetic Markers
- Genetic Predisposition to Disease
- Herpesviridae Infections
- Humans
- Hybridomas
- Immunity, Innate
- Killer Cells, Natural