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Article

Apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging.

Neurobiology of aging - 1 Jun 2014

Roussotte Florence F, Gutman Boris A, Madsen Sarah K, Colby John B, Narr Katherine L, Thompson Paul M

Abstract excerpt

The apolipoprotein E epsilon 4 allele (ApoE-ε4) is the strongest known genetic risk factor for late onset Alzheimer's disease. Expansion of the lateral ventricles occurs with normal aging, but dementia accelerates this process. Brain structure and function depend on ApoE genotype not just for Alzheimer's disease patients but also in healthy elderly individuals, and even in asymptomatic young individuals....

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Identifiers

PMID: 24411483
DOI: 10.1016/j.neurobiolaging.2013.11.030
PMCID: PMC3961511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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