Article
Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease.
Current Alzheimer research - 1 Jan 2022
Hamza Eid Abo, Moustafa Ahmed A, Tindle Richard, Karki Rasu, Nalla Shahed, Hamid Mohamed S, El Haj Mohamad
Abstract excerpt
BACKGROUND: The hippocampus, entorhinal cortex, and fusiform gyrus are brain areas that deteriorate during early-stage Alzheimer's disease (AD). The ApoE4 allele has been identified as a risk factor for AD development, is linked to an increase in the aggregation of amyloid β (Aβ) plaques in the brain, and is responsible for atrophy of the hippocampal area. However, to our knowledge, the rate of deterioration over...
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