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Article

Apolipoprotein E and gray matter volume loss in patients with mild cognitive impairment and Alzheimer disease.

Radiology - 1 Mar 2011

Spampinato Maria Vittoria, Rumboldt Zoran, Hosker Robert J, Mintzer Jacobo E

Abstract excerpt

PURPOSE: To examine the influence of apoliprotein E ε4 allele (APOE4) carrier status on disease progression by evaluating the rate of regional gray matter (GM) volume loss and disease severity in patients with newly diagnosed Alzheimer disease (AD) and stable amnestic mild cognitive impairment (MCI). MATERIALS AND METHODS: This study was approved by the institutional review board and was HIPAA compliant. All...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Atrophy
Biomarkers
Cognition Disorders
Female
Humans
Image Processing, Computer-Assisted

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Male

Middle Aged

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21163916
DOI: 10.1148/radiol.10100307
PMCID: PMC6939949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21163916-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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