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Article

Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period.

Journal of Alzheimer's disease : JAD - 1 Feb 2025

Park Chang Hyun, Lee Hyunji, Lee Young-Min, Lee Byung-Dae, Moon Eunsoo, Suh Hwagyu, Kim Kyungwon, Kim Hak-Jin, Shim Hwanwook, Pak Kyoungjune, Choi Kyung-Un, Kim Chang-Seok

Abstract excerpt

BACKGROUND: Hippocampal atrophy is implicated in the early onset of Alzheimer's disease (AD). It is closely associated with rapid cognitive decline and serves as a critical predictor for conversion from mild cognitive impairment (MCI) to AD. Consequently, with growing interest in utilizing hippocampal volume (HV) as an outcome measure in clinical trials, elucidating the neurobiological mechanisms underlying...

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PMID: 39924830
DOI: 10.1177/13872877241313066

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