Article
Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension.
Journal of the American Heart Association - 10 Nov 2014
Fontana Vanessa, McDonough Caitrin W, Gong Yan, El Rouby Nihal M, Sá Ana Caroline C, Taylor Kent D, Chen Y-D Ida, Gums John G, Chapman Arlene B, Turner Stephen T, Pepine Carl J, Johnson Julie A, Cooper-DeHoff Rhonda M
Abstract excerpt
BACKGROUND: Resistant hypertension (RHTN), defined by lack of blood pressure (BP) control despite treatment with at least 3 antihypertensive drugs, increases cardiovascular risk compared with controlled hypertension. Yet, there are few data on genetic variants associated with RHTN. METHODS AND RESULTS: We used a gene-centric array containing ≈50 000 single-nucleotide polymorphisms (SNPs) to identify polymorphisms...
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