Article
Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.
Hypertension (Dallas, Tex. : 1979) - 1 May 2011
Johnson Andrew D, Newton-Cheh Christopher, Chasman Daniel I, Ehret Georg B, Johnson Toby, Rose Lynda, Rice Kenneth, Verwoert Germaine C, Launer Lenore J, Gudnason Vilmundur, Larson Martin G, Chakravarti Aravinda, Psaty Bruce M, Caulfield Mark, van Duijn Cornelia M, Ridker Paul M, Munroe Patricia B, Levy Daniel
Abstract excerpt
We previously conducted genome-wide association meta-analysis of systolic blood pressure, diastolic blood pressure, and hypertension in 29,136 people from 6 cohort studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Here we examine associations of these traits with 30 gene regions encoding known antihypertensive drug targets. We find nominal evidence of association of ADRB1,...
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