Article
Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2026
Tragante Vinicius, Sulem Patrick, Thorleifsson Gudmar, Frigge Michael L, Arthur Joseph G, Asselbergs Folkert W, Banasik Karina, Brunak Søren, Christensen Alex H, Crawford Dana C, Deaton Aimee M, Erikstrup Christian, Ferkingstad Egil, Ghouse Jonas, Gretarsdottir Solveig, Halldorsson Gisli H, Helgadottir Anna, Iversen Kasper K, Jonsdottir Ingileif, Knowlton Kirk U, Kristjansson Ragnar P, Larusdottir Adalheidur E, Lund Sigrun H, Magnusson Magnus I, Melsted Pall, Nyegaard Mette, Oddsson Asmundur, Olafsson Isleifur, Olesen Morten S, Ostrowski Sisse R, Palsson Runolfur, Pedersen Ole B, Sigurdardottir Olof, Stefansdottir Lilja, Arnar David O, Sveinbjornsson Gardar, Masson Gisli, Sigurdsson Emil L, Thorgeirsson Gudmundur, Ullum Henrik, Nadauld Lincoln D, Thorsteinsdottir Unnur, Bundgaard Henning, Gudbjartsson Daniel F, Stefansson Kari, Holm Hilma
Abstract excerpt
BACKGROUND: We aimed to characterize the genetic architecture of resistant hypertension (rHTN), which affects up to 18% of hypertensive individuals and increases cardiovascular disease risk. METHODS: We conducted a genome-wide association study on rHTN, defined as use of 3 or more concomitant antihypertensive drugs for at least 6 months without reaching blood pressure target (in the 3-drug case), comparing it to...
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