Article

Assessing the efficacy and safety of angiotensinogen inhibition using human genetics

2020-08-14

Abstract excerpt

<h4>Background</h4> Novel angiotensinogen (AGT) inhibitors are in early clinical development for treatment of hypertension. Evidence that this therapeutic approach will safely reduce risk of cardiovascular outcomes in humans is limited. We leveraged genetic data from more than one million individuals to characterise the effects of AGT inhibition. <h4>Methods</h4> We identified a genetic instrument for AGT inhibiti...

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Literature Corpus work: 039ae8aa-d78a-5a3c-942f-bfa90c061f2d
DOI: 10.1101/2020.08.13.20174094

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