Article
Genetic variation in the beta2 subunit of the voltage-gated calcium channel and pharmacogenetic association with adverse cardiovascular outcomes in the INternational VErapamil SR-Trandolapril STudy GENEtic Substudy (INVEST-GENES).
Circulation. Cardiovascular genetics - 1 Dec 2010
Niu Yuxin, Gong Yan, Langaee Taimour Y, Davis Heather M, Elewa Hazem, Beitelshees Amber L, Moss James I, Cooper-Dehoff Rhonda M, Pepine Carl J, Johnson Julie A
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNPs) within the regulatory β2 subunit of the voltage-gated calcium channel (CACNB2) may contribute to variable treatment response to antihypertensive drugs and adverse cardiovascular outcomes. METHODS AND RESULTS: SNPs in CACNB2 from 60 ethnically diverse individuals were identified and characterized. Three common SNPs (rs2357928, rs7069292, and rs61839258) and a...
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