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Article

TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways.

The Journal of biological chemistry - 7 May 2010

Czirják Gábor, Enyedi Péter

Abstract excerpt

The two-pore domain K(+) channel, TRESK (TWIK-related spinal cord K(+) channel, KCNK18) is directly regulated by the calcium/calmodulin-dependent phosphatase calcineurin and 14-3-3 adaptor proteins. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3 interferes with the return of the current to the resting state after the activation in Xenopus oocytes. In the present...

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Source

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Identifiers

PMID: 20215114
DOI: 10.1074/jbc.M110.102020
PMCID: PMC2863173

Genes

KCNK18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways.PMID 20215114Read ↗

Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.Semantic proximity Read ↗

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