Article
Subgroups at high risk for ischaemic heart disease:identification and validation in 67 000 individuals from the general population.
International journal of epidemiology - 1 Feb 2015
Frikke-Schmidt Ruth, Tybjærg-Hansen Anne, Dyson Greg, Haase Christiane L, Benn Marianne, Nordestgaard Børge G, Sing Charles F
Abstract excerpt
BACKGROUND: The aetiology of ischaemic heart disease (IHD) is complex and is influenced by a spectrum of environmental factors and susceptibility genes. Traditional statistical modelling considers such factors to act independently in an additive manner. The Patient Rule-Induction Method (PRIM) is a multi-model building strategy for evaluating risk attributable to context-dependent gene and environmental effects....
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