Article
Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: a population-based study in Greece.
BMJ open - 5 Feb 2014
Yiannakouris Nikos, Katsoulis Michail, Trichopoulou Antonia, Ordovas Jose M, Trichopoulos Dimitrios
Abstract excerpt
OBJECTIVES: An additive genetic risk score (GRS) for coronary heart disease (CHD) has previously been associated with incident CHD in the population-based Greek European Prospective Investigation into Cancer and nutrition (EPIC) cohort. In this study, we explore GRS-'environment' joint actions on CHD for several conventional cardiovascular risk factors (ConvRFs), including smoking, hypertension, type-2 diabetes...
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