Article

A Weighted PRS for Ischemic Heart Disease: Candidate-Gene Associations and an Evaluation of Epistasis and Machine-Learning Approaches

2026-08-06

Abstract excerpt

<title>Abstract</title> <p> Ischemic heart disease (IHD) carries a substantial polygenic component, but candidate-gene and polygenic-score evidence remains scarce in South Asians. This Pakistani case–control study evaluated eight candidate variants, their aggregation into conventional and epistasis-weighted polygenic scores, and machine-learning classifiers. 612 participants (306 IHD cases, 306 controls) were ge...

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Literature Corpus work: ac923cb2-3d0a-52a5-9a38-e137f845cd10
DOI: 10.21203/rs.3.rs-10560334/v1

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