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Article

Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.

Pharmacogenetics and genomics - 1 May 2012

Lynch Amy I, Eckfeldt John H, Davis Barry R, Ford Charles E, Boerwinkle Eric, Leiendecker-Foster Catherine, Arnett Donna K

Abstract excerpt

OBJECTIVE: To identify panels of genetic variants that predict treatment-related coronary heart disease (CHD) outcomes in hypertensive patients on one of four different classes of initial antihypertensive treatment. The goal was to identify subgroups of individuals on the basis of their genetic profile who benefit most from a particular treatment. METHODS: Candidate genetic variants (n=78) were genotyped in 39...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22388798
DOI: 10.1097/FPC.0b013e3283516ff8
PMCID: PMC3325375

Genes

AGT
ACE
GNAS
ICAM1
MMP1
MMP12
MMP2
MMP7
MMP9
NOS3
NPPA
PON1
SELE

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