Article
Validated context-dependent associations of coronary heart disease risk with genotype variation in the chromosome 9p21 region: the Atherosclerosis Risk in Communities study.
Human genetics - 1 Sept 2014
Lusk Christine M, Dyson Greg, Clark Andrew G, Ballantyne Christie M, Frikke-Schmidt Ruth, Tybjærg-Hansen Anne, Boerwinkle Eric, Sing Charles F
Abstract excerpt
Markers of the chromosome 9p21 region are regarded as the strongest and most reliably significant genome-wide association study (GWAS) signals for Coronary heart disease (CHD) risk; this was recently confirmed by the CARDIoGRAMplusC4D Consortium meta-analysis. However, while these associations are significant at the population level, they may not be clinically relevant predictors of risk for all individuals. We...
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