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Article

Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish women.

Circulation. Cardiovascular genetics - 1 Feb 2010

Stengård Jari H, Dyson Greg, Frikke-Schmidt Ruth, Tybjaerg-Hansen Anne, Nordestgaard Borge G, Sing Charles F

Abstract excerpt

OBJECTIVE: Variations in the noncoding single-nucleotide polymorphisms (SNPs) at positions 560 and 832 in the 5' promoter region of the apolipoprotein E gene define genotypes that distinguish between high and low concentrations of plasma total and high-density lipoprotein cholesterol and triglycerides. We addressed whether these genotypes improve the prediction of ischemic heart disease (IHD) in subsamples of...

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Identifiers

PMID: 20160192
DOI: 10.1161/CIRCGENETICS.109.862748
PMCID: PMC2851145

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