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Article

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study.

Molecular bioSystems - 1 Jan 2015

Curtain Cyril C, Kirby Nigel M, Mertens Haydyn D T, Barnham Kevin J, Knott Robert B, Masters Colin L, Cappai Roberto, Rekas Agata, Kenche Vijaya B, Ryan Timothy

Abstract excerpt

The 140 residue intrinsically disordered protein α-synuclein (α-syn) self-associates to form fibrils that are the major constituent of the Lewy body intracellular protein inclusions, and neurotoxic oligomers. Both of these macromolecular structures are associated with a number of neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies. Using ensemble optimisation modelling (EOM)...

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PMID: 25352253
DOI: 10.1039/c4mb00356j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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