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Article

Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.

Biochemical and biophysical research communications - 23 Sept 2005

Sode Koji, Usuzaka Eri, Kobayashi Natsuki, Ochiai Sayaka

Abstract excerpt

Alpha-synuclein is a major component of several pathological lesions diagnostic of specific neurodegenerative disease such as Parkinson's disease. This study focuses on the non-amyloid beta component of Alzheimer's disease amyloid, a key region for the aggregation and fibril formation of alpha-synuclein. Several mutations were introduced in an attempt to repress beta-strand formation and hydrophobic...

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Identifiers

PMID: 16081040
DOI: 10.1016/j.bbrc.2005.07.100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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