Familial Parkinson Disease-associated Mutations Alter the Site-specific Microenvironment and Dynamics of α-Synuclein

Abstract excerpt

Human α-synuclein (α-Syn) is a natively unstructured protein whose aggregation into amyloid fibrils is associated with Parkinson disease (PD) pathogenesis. Mutations of α-Syn, E46K, A53T, and A30P, have been linked to the familial form of PD. In vitro aggregation studies suggest that increased propensity to form non-fibrillar oligomers is the shared property of these familial PD-associated mutants. However, the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neurological disorders and treatments
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments