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Article

The Drosophila Tis11 protein and its effects on mRNA expression in flies.

The Journal of biological chemistry - 19 Dec 2014

Choi Youn-Jeong, Lai Wi S, Fedic Robert, Stumpo Deborah J, Huang Weichun, Li Leping, Perera Lalith, Brewer Brandy Y, Wilson Gerald M, Mason James M, Blackshear Perry J

Abstract excerpt

Members of the mammalian tristetraprolin family of CCCH tandem zinc finger proteins can bind to certain AU-rich elements (AREs) in mRNAs, leading to their deadenylation and destabilization. Mammals express three or four members of this family, but Drosophila melanogaster and other insects appear to contain a single gene, Tis11. We found that recombinant Drosophila Tis11 protein could bind to ARE-containing RNA...

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Identifiers

PMID: 25342740
DOI: 10.1074/jbc.M114.593491
PMCID: PMC4271196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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