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Article

Direct binding of specific AUF1 isoforms to tandem zinc finger domains of tristetraprolin (TTP) family proteins.

The Journal of biological chemistry - 17 Feb 2012

Kedar Vishram P, Zucconi Beth E, Wilson Gerald M, Blackshear Perry J

Abstract excerpt

Tristetraprolin (TTP) is the prototype of a family of CCCH tandem zinc finger proteins that can bind to AU-rich elements in mRNAs and promote their decay. TTP binds to mRNA through its central tandem zinc finger domain; it then promotes mRNA deadenylation, considered to be the rate-limiting step in eukaryotic mRNA decay. We found that TTP and its related family members could bind to certain isoforms of another...

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Identifiers

PMID: 22203679
DOI: 10.1074/jbc.M111.312652
PMCID: PMC3325588

Genes

HNRNPD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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