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Article

The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2005

Clouaire Thomas, Roussigne Myriam, Ecochard Vincent, Mathe Catherine, Amalric François, Girard Jean-Philippe

Abstract excerpt

We have recently described an evolutionarily conserved protein motif, designated the THAP domain, which defines a previously uncharacterized family of cellular factors (THAP proteins). The THAP domain exhibits similarities to the site-specific DNA-binding domain of Drosophila P element transposase, including a putative metal-coordinating C2CH signature (CX(2-4)CX(35-53)CX(2)H). In this article, we report a...

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Source

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Identifiers

PMID: 15863623
DOI: 10.1073/pnas.0406882102
PMCID: PMC1100732

Genes

THAP1
THAP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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