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Article

The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis.

Cancer research - 15 Jun 2009

Brennan Sarah E, Kuwano Yuki, Alkharouf Nadim, Blackshear Perry J, Gorospe Myriam, Wilson Gerald M

Abstract excerpt

AU-rich element-binding proteins (ARE-BP) regulate the stability and/or translational efficiency of mRNAs containing cognate binding sites. Many targeted transcripts encode factors that control processes such as cell division, apoptosis, and angiogenesis, suggesting that dysregulated ARE-BP expression could dramatically influence oncogenic phenotypes. Using several approaches, we evaluated the expression of four...

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Identifiers

PMID: 19491267
DOI: 10.1158/0008-5472.CAN-08-4238
PMCID: PMC2724875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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