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Article

A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum.

Nucleic acids research - 18 Nov 2021

Bai Wenli, Wells Melissa L, Lai Wi S, Hicks Stephanie N, Burkholder Adam B, Perera Lalith, Kimmel Alan R, Blackshear Perry J

Abstract excerpt

Post-transcriptional processes mediated by mRNA binding proteins represent important control points in gene expression. In eukaryotes, mRNAs containing specific AU-rich motifs are regulated by binding of tristetraprolin (TTP) family tandem zinc finger proteins, which promote mRNA deadenylation and decay, partly through interaction of a conserved C-terminal CNOT1 binding (CNB) domain with CCR4-NOT protein...

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PMID: 34718768
DOI: 10.1093/nar/gkab983
PMCID: PMC8599788

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