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Article

Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.

Molecular and cellular biology - 1 Oct 2012

Wells Melissa L, Huang Weichun, Li Leping, Gerrish Kevin E, Fargo David C, Ozsolak Fatih, Blackshear Perry J

Abstract excerpt

Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins can bind directly to AU-rich elements in mRNAs and promote transcript deadenylation and decay. The yeast Schizosaccharomyces pombe expresses a single TTP family member, Zfs1p. In this study, we identified probable Zfs1p target mRNAs by comparing transcript levels in wild-type yeast and zfs1Δ mutants, using deep sequencing and...

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Identifiers

PMID: 22907753
DOI: 10.1128/MCB.00325-12
PMCID: PMC3457339

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