Article
Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.
Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 2016
Patial Sonika, Curtis Alan D, Lai Wi S, Stumpo Deborah J, Hill Georgette D, Flake Gordon P, Mannie Mark D, Blackshear Perry J
Abstract excerpt
Tristetraprolin (TTP) is an inducible, tandem zinc-finger mRNA binding protein that binds to adenylate-uridylate-rich elements (AREs) in the 3'-untranslated regions (3'UTRs) of specific mRNAs, such as that encoding TNF, and increases their rates of deadenylation and turnover. Stabilization of Tnf mRNA and other cytokine transcripts in TTP-deficient mice results in the development of a profound, chronic...
Topics
- Aminoquinolines
- Animals
- Arthritis, Experimental
- Cells, Cultured
- Collagen
- Dermatitis
- Encephalomyelitis, Autoimmune, Experimental
- Imiquimod
- Inflammation
- Mice