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Article

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.

Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 2016

Patial Sonika, Curtis Alan D, Lai Wi S, Stumpo Deborah J, Hill Georgette D, Flake Gordon P, Mannie Mark D, Blackshear Perry J

Abstract excerpt

Tristetraprolin (TTP) is an inducible, tandem zinc-finger mRNA binding protein that binds to adenylate-uridylate-rich elements (AREs) in the 3'-untranslated regions (3'UTRs) of specific mRNAs, such as that encoding TNF, and increases their rates of deadenylation and turnover. Stabilization of Tnf mRNA and other cytokine transcripts in TTP-deficient mice results in the development of a profound, chronic...

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Identifiers

PMID: 26831084
DOI: 10.1073/pnas.1519906113
PMCID: PMC4763790

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.PMID 26831084Read ↗

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