Article
Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.
Molecular and cellular biology - 1 Jul 2004
Stumpo Deborah J, Byrd Noah A, Phillips Ruth S, Ghosh Sanjukta, Maronpot Robert R, Castranio Trisha, Meyers Erik N, Mishina Yuji, Blackshear Perry J
Abstract excerpt
The mouse gene Zfp36L1 encodes zinc finger protein 36-like 1 (Zfp36L1), a member of the tristetraprolin (TTP) family of tandem CCCH finger proteins. TTP can bind to AU-rich elements within the 3'-untranslated regions of the mRNAs encoding tumor necrosis factor (TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), leading to accelerated mRNA degradation. TTP knockout mice exhibit an inflammatory...
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