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Article

Structural perspective on mutations affecting the function of multisubunit RNA polymerases.

Microbiology and molecular biology reviews : MMBR - 1 Mar 2006

Trinh Vincent, Langelier Marie-France, Archambault Jacques, Coulombe Benoit

Abstract excerpt

High-resolution crystallographic structures of multisubunit RNA polymerases (RNAPs) have increased our understanding of transcriptional mechanisms. Based on a thorough review of the literature, we have compiled the mutations affecting the function of multisubunit RNA polymerases, many of which having been generated and studied prior to the publication of the first high-resolution structure, and highlighted the...

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Identifiers

PMID: 16524917
DOI: 10.1128/MMBR.70.1.12-36.2006
PMCID: PMC1393249

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