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Article

Activity map of the Escherichia coli RNA polymerase bridge helix.

The Journal of biological chemistry - 22 Apr 2011

Jovanovic Milija, Burrows Patricia C, Bose Daniel, Cámara Beatriz, Wiesler Simone, Zhang Xiaodong, Wigneshweraraj Sivaramesh, Weinzierl Robert O J, Buck Martin

Abstract excerpt

Transcription, the synthesis of RNA from a DNA template, is performed by multisubunit RNA polymerases (RNAPs) in all cellular organisms. The bridge helix (BH) is a distinct feature of all multisubunit RNAPs and makes direct interactions with several active site-associated mobile features implicated in the nucleotide addition cycle and RNA and DNA binding. Because the BH has been captured in both kinked and...

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Identifiers

PMID: 21357417
DOI: 10.1074/jbc.M110.212902
PMCID: PMC3077646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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