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Article

Interplay between the trigger loop and the F loop during RNA polymerase catalysis.

Nucleic acids research - 1 Jan 2014

Miropolskaya Nataliya, Esyunina Daria, Klimasauskas Saulius, Nikiforov Vadim, Artsimovitch Irina, Kulbachinskiy Andrey

Abstract excerpt

The trigger loop (TL) in the RNA polymerase (RNAP) active center plays key roles in the reactions of nucleotide addition and RNA cleavage catalyzed by RNAP. The adjacent F loop (FL) was proposed to contribute to RNAP catalysis by modulating structural changes in the TL. Here, we investigate the interplay between these two elements during transcription by bacterial RNAP. Thermodynamic analysis of catalysis by RNAP...

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Identifiers

PMID: 24089145
DOI: 10.1093/nar/gkt877
PMCID: PMC3874190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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