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Article

Conserved functions of the trigger loop and Gre factors in RNA cleavage by bacterial RNA polymerases.

The Journal of biological chemistry - 21 Apr 2017

Miropolskaya Nataliya, Esyunina Daria, Kulbachinskiy Andrey

Abstract excerpt

RNA cleavage by RNA polymerase (RNAP) is the central step in co-transcriptional RNA proofreading. Bacterial RNAPs were proposed to rely on the same mobile element of the active site, the trigger loop (TL), for both nucleotide addition and RNA cleavage. RNA cleavage can also be stimulated by universal Gre factors, which should replace the TL to get access to the RNAP active site. The contributions of the TL and...

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Identifiers

PMID: 28242762
DOI: 10.1074/jbc.M116.766592
PMCID: PMC5399121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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