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Article

Activation and reactivation of the RNA polymerase II trigger loop for intrinsic RNA cleavage and catalysis.

Transcription - 1 Jan 2014

Čabart Pavel, Jin Huiyan, Li Liangtao, Kaplan Craig D

Abstract excerpt

In addition to RNA synthesis, multisubunit RNA polymerases (msRNAPs) support enzymatic reactions such as intrinsic transcript cleavage. msRNAP active sites from different species appear to exhibit differential intrinsic transcript cleavage efficiency and have likely evolved to allow fine-tuning of the transcription process. Here we show that a single amino-acid substitution in the trigger loop (TL) of...

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Identifiers

PMID: 25764335
DOI: 10.4161/trns.28869
PMCID: PMC4574878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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