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Article

A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran.

Iranian biomedical journal - 1 Jan 2014

Hashemi Mohammad, Omrani Mohsen, Eskandari-Nasab Ebrahim, Hasani Seyed-Shahaboddin, Mashhadi Mohammad Ali, Taheri Mohsen

Abstract excerpt

BACKGROUND: MDM2 (Murine Double Minute2) is an oncoprotein that inhibits the P53 activity. Overexpression of MDM2 gene has been reported in several human tumors. In the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of MDM2 and susceptibility to breast cancer in a sample of Iranian population. METHODS: This case-control study was carried out on...

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Identifiers

PMID: 25326024
DOI: 10.6091/ibj.13332.2014
PMCID: PMC4225065

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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