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Article

Murine double minute clone 2,309T/G and 285G/C promoter single nucleotide polymorphism as a risk factor for breast cancer: a Polish experience.

The International journal of biological markers - 19 Jul 2012

Piotrowski Piotr, Lianeri Margarita, Rubis Błazej, Knuła Hanna, Rybczyńska Maria, Grodecka-Gazdecka Sylwia, Jagodziński Paweł P

Abstract excerpt

BACKGROUND: Breast cancer is a multifactorial disease caused by complex interactions between genetic and environmental factors. Recently, a functional polymorphism, MDM2 285G>C (rs117039649), has been discovered. This polymorphism antagonizes the effect of the 309T>G (rs2279744) polymorphism on the same gene, resulting in decreased MDM2 transcription. METHODS: The MDM2 285G>C and 309T>G polymorphisms were...

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Source

Identifiers

PMID: 22467100
DOI: 10.5301/JBM.2012.9140

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Murine double minute clone 2,309T/G and 285G/C promoter single nucleotide polymorphism as a risk factor for breast cancer: a Polish experience.PMID 22467100Read ↗

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A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran.Semantic proximity Read ↗

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Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer.Semantic proximity Read ↗

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Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.Semantic proximity Read ↗

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