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Article

Association of Single Nucleotide Polymorphisms of the MDM4 Gene With the Susceptibility to Breast Cancer in a Southeast Iranian Population Sample.

Clinical breast cancer - 1 Oct 2018

Hashemi Mohammad, Sanaei Sara, Hashemi Seyeh Mehdi, Eskandari Ebrahim, Bahari Gholamreza

Abstract excerpt

INTRODUCTION: The murine double minute 4 (MDM4) protein is a negative regulator of p53, and its upregulation has been observed in many tumor types. Previous literature suggested that genetic variations in the MDM4 gene are associated with risk of different cancers. The objective of the present study was to examine the effect of 3 common genetic variants of MDM4, rs4245739 A>C, rs11801299 G>A, and rs1380576 C>G,...

Topics

Adult
Breast Neoplasms
Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cell Cycle Proteins

Female

Genetic Association Studies

Genetic Predisposition to Disease

Genotype

Humans

Iran

Middle Aged

Nuclear Proteins

Odds Ratio

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Proto-Oncogene Proteins

Source

Identifiers

PMID: 29439926
DOI: 10.1016/j.clbc.2018.01.003

Genes

MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association of Single Nucleotide Polymorphisms of the MDM4 Gene With the Susceptibility to Breast Cancer in a Southeast Iranian Population Sample.PMID 29439926Read ↗

Analysis of the Association between MDM4 rs4245739 Single Nucleotide Polymorphism and Breast Cancer Susceptibility.Semantic proximity Read ↗

Exploring the Relationship Between MDM4 Gene Polymorphisms (rs1380576 and rs4245739) and Breast Cancer Susceptibility in Bangladesh: A Case-Control StudySemantic proximity Read ↗

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Exploring the Relationship Between MDM4 Gene Polymorphisms (rs1380576 and rs4245739) and Breast Cancer Susceptibility in Bangladesh: A Case-Control Study.Semantic proximity Read ↗

A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran.Semantic proximity Read ↗

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