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Article

Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish Population

Asian Pacific journal of cancer prevention : APJCP - 27 Apr 2018

Yilmaz Meral, Tas Ayca, Donmez Gonca, Kacan Turgut, Silig Yavuz

Abstract excerpt

Background: Breast cancer is a leading cause of death in women worldwide. Genetic polymorphisms have been reported to be important etiological factors. Murine double minute 2 (MDM2) T309G interacts with p53 and mutations in p53 are present in approximately 50% of all cancers. However, it has been reported that effect of the polymorphism on breast cancer risk may vary in different populations. Here, we therefore...

Topics

Adult
Aged
Aged, 80 and over
Breast
Breast Neoplasms
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Proto-Oncogene Proteins c-mdm2

Risk Factors

Turkey

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 29699057
DOI: 10.22034/APJCP.2018.19.4.1059
PMCID: PMC6031795

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish PopulationPMID 29699057Read ↗

MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.Semantic proximity Read ↗

Murine double minute clone 2,309T/G and 285G/C promoter single nucleotide polymorphism as a risk factor for breast cancer: a Polish experience.Semantic proximity Read ↗

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Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population.Semantic proximity Read ↗

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.Semantic proximity Read ↗

A case-control study on the SNP309T → G and 40-bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer.Semantic proximity Read ↗

Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis.Semantic proximity Read ↗

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